FITC标记的细胞周期调控蛋白SDP35抗体
产品名称： FITC标记的细胞周期调控蛋白SDP35抗体
英文名称： Anti-DEPDC1/FITC
产品编号： HZ-6525R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-DEPDC1/FITC Conjugated antibody
FITC标记的细胞周期调控蛋白SDP35抗体
| 英文名称 | Anti-DEPDC1/FITC |
| 中文名称 | FITC标记的细胞周期调控蛋白SDP35抗体 |
| 别 名 | Cell cycle control protein SDP35; DEP domain containing 1; DEP domain containing protein 1A; DEP domain-containing protein 1A; DEP.8; DEP1A_HUMAN; DEPDC 1; DEPDC 1A; DEPDC1; DEPDC1-V2; Depdc1a; FLJ20354; SDP 35; SDP35. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 肿瘤细胞生物标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 93kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DEPDC1 (606-660aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DEPDC1 is a 784 amino acid nuclear protein expressed in testis and up-regulated in bladder cancer cells. Containing a DEP domain and a Rho-GAP domain, DEPDC1 may play an essential role in the growth of bladder cancer cells, and is considered a novel protein target for bladder cancer therapy. Existing as five isoforms produced by alternative splicing events, DEPDC1 is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma Function: May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. Subunit: Isoform 2 and isoform 5 can form homodimers and heterodimers. Interacts with ZNF224. Subcellular Location: Nucleus. Note=Co-localizes with ZNF224 at the nucleus. Tissue Specificity: Expressed in testis. Up-regulated in bladder cancer cells (at protein level). Similarity: Contains 1 DEP domain. Contains 1 Rho-GAP domain. Database links: Entrez Gene: 55635 Human Omim: 612002 Human SwissProt: Q5TB30 Human Unigene: 445098 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
DEPDC1是一种在睾丸中表达的784氨基酸核蛋白，在膀胱癌细胞中表达上调。DEPDC1包含DEP结构域和Rho间隙结构域，在膀胱癌细胞的生长中起着重要的作用，被认为是膀胱癌治疗的一种新的蛋白靶点。作为选择性剪接事件产生的五种异构体，DEPDC1由位于人类染色体1上的基因编码，该基因跨越2亿6000万个碱基对，包含超过3000个基因，并包含人类基因组的近8%。1号染色体含有大量的疾病相关基因，包括家族性腺瘤性息肉病、Stutkle综合征、帕金森氏病、高雪氏病、精神分裂症和阿瑟小子综合征。染色体1的畸变在多种癌症中发现，包括头颈部癌、恶性黑色素瘤和多发性骨髓瘤。