FITC标记的电压门控钾通道亚基Kv7.3抗体
产品名称： FITC标记的电压门控钾通道亚基Kv7.3抗体
英文名称： Anti-KCNQ3/FITC
产品编号： HZ-16912R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-KCNQ3/FITC Conjugated antibody
FITC标记的电压门控钾通道亚基Kv7.3抗体
| 英文名称 | Anti-KCNQ3/FITC |
| 中文名称 | FITC标记的电压门控钾通道亚基Kv7.3抗体 |
| 别 名 | BFNC 2; BFNC; BFNC2; EBN 2; EBN2; KCNQ 3; KCNQ3; KCNQ3_HUMAN; KQT like 3; KQT-like 3; KV7.3; Potassium channel subunit alpha KvLQT3; Potassium channel voltage gated subfamily Q member 3; Potassium voltage gated channel KQT like protein 3; Potassium voltage gated channel KQT like subfamily member 3; Potassium voltage gated channel subfamily KQT member 3; Potassium voltage-gated channel subfamily KQT member 3; Voltage gated potassium channel subunit Kv7.3; Voltage-gated potassium channel subunit Kv7.3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 97kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KCNQ3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found. [provided by RefSeq, Mar 2011] Function: Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Subcellular Location: Membrane. Tissue Specificity: Predominantly expressed in brain. DISEASE: Defects in KCNQ3 are the cause of benign neonatal epilepsy type 2 (EBN2) [MIM:121201]. Benign neonatal epilepsy is characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. Similarity: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily. Database links: Entrez Gene: 3786 Human Entrez Gene: 110862 Mouse Entrez Gene: 29682 Rat Omim: 602232 Human SwissProt: O43525 Human SwissProt: Q8K3F6 Mouse SwissProt: O88944 Rat Unigene: 374023 Human Unigene: 255585 Mouse Unigene: 205060 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
M通道是缓慢激活和失活的钾通道，在调节神经元兴奋性方面起着关键作用。M通道是由该基因编码的蛋白与两个相关蛋白之一结合形成的，这两个相关蛋白都是完整的膜蛋白，由KCNQ2和KCNQ5基因编码。M通道电流被M1毒蕈碱乙酰胆碱受体抑制，被新型抗惊厥药物维甲酸激活。该基因的缺陷是良性家族性新生儿惊厥2型（BFNC2），也称为癫痫，良性新生儿2型（EBN2）。已经发现了编码不同亚型的两个变体。〔RefSeq，2011〕