FITC标记的信号通路Wnt2B抗体
产品名称： FITC标记的信号通路Wnt2B抗体
英文名称： Anti-WNT2B/FITC
产品编号： HZ-1946R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-WNT2B/FITC Conjugated antibody
FITC标记的信号通路Wnt2B抗体
| 英文名称 | Anti-WNT2B/FITC |
| 中文名称 | FITC标记的信号通路Wnt2B抗体 |
| 别 名 | wingless-type MMTV integration site family, member 2B; XWNT2; WNT13; WNT2B_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human WNT2B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: WNT2B is a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternative transcript variants.This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternative transcript variants. Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis. Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines. Post-translational modifications: Palmitoylation at Ser-243 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-107. Palmitoylation is necessary for proper trafficking to cell surface (By similarity). Similarity: Belongs to the Wnt family. Database links: Entrez Gene: 445420 Cow Entrez Gene: 7482 Human Entrez Gene: 22414 Mouse Entrez Gene: 116466 Rat Omim: 601968 Human SwissProt: Q93097 Human SwissProt: O70283 Mouse Unigene: 27254 Cow Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
WNT2B是无翅型MMTV整合位点（Wnt）家族中高度保守、分泌信号因子的成员。Wnt家族成员在多种发育过程中起作用，包括调节细胞生长和分化，其特征在于Wnt核心结构域。该基因可能在人类发展和人类癌变中发挥作用。该基因产生两种可供选择的转录变体，该基因编码无翅型MMTV整合位点（Wnt）家族中高度保守、分泌的信号因子。Wnt家族成员在多种发育过程中起作用，包括调节细胞生长和分化，其特征在于Wnt核心结构域。该基因可能在人类发展和人类癌变中发挥作用。该基因产生两种可供选择的转录变体。